From 2015 to 2020, approximately 20 MS centers will be recruited to participate in NARCRMS. We will initially begin with one site at the University of Miami, the project director’s site, and then expand to 5 sites by 2016. Clinical sites and medical practices currently enrolled in the CMSC, as well as affiliate centers of the National MS Society, will be invited to participate in NARCRMS if they are willing to become one of the twenty sites that enroll patients. Sites will be chosen to geographically represent all parts of the US and possibly, parts of Canada.